Product Code: L04AA13
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Buy Leflunomide Online (Avara) 100 mg 30 Tablets (or Arava 20mg 30 Tablets)


Arava  is a drug used for the treatment of severe rheumatoid arthritis. It is approved among the disease-modifying antirheumatic drugs (DMARDs). DMARDs ease the joint damage caused by rheumatoid arthritis. It is generally used alone, but sometimes combined with other DMARDs, but not with methotrexate. 

What are the Ingredients of Arava? What does Arava contain?

The Active ingredient of Arava is Leflunomide. Other supporting ingredients are:


- Core of the Tablet: Lactose monohydrate, corn starch, PolyVidon K 25, collodial anhydrous silica, magnesium stearate, crospovidone. 

- Film Coating: Hypromellose, macrogol 8000, titanium dioxide (E 171), yellow iron oxide (E172), talc.


What is Arava used for? What are the Indications of Arava?

In adults, Arava is used in cases of active rheumatoids that do not tolerate drugs or the drug is contraindicated arthritis. It can also be suggested if the illness is not controlled by sulfasalazine or methotrexate and if the treatment of active psoriatic arthritis in which the use of these drugs is contraindicated.


The symptoms of the Rheumatoid are inflammation, swelling, difficulty in movement and pain in the affected parts of the body. Some rare symptoms influencing the body negatively are loss of appetite, fever, decreased energy and anemia.


Inflammation, swelling, difficulty in movement, pain and patchy red scaly skin patches are indication of active psoriatic arthritis.


What are the Contraindications of Arava?


Arava should not be used in cases of a problem in the liver regarding Leflunomide or the auxiliary in tablets. If you have hypersensitivity to any of the substances of the ingredients of Arava, you should not take it.If the hypersensivity us especially like fever, joint pain, in the form of severe skin reactions in the form of deep red stains or bumps, do not use Arava.  


If you also have the below problems, do not use Arava:


- Liver dysfunction 

- Severe kidney problems 

- Under normal blood protein level is (hypoproteinemia) 

- Discomfort affecting your immune system (eg AIDS) 

- Marrow-related illness, red or white blood cells or blood platelets


In case of pregnacy or breastfeeding or a serious infection, do not use Arava. 


Under certain circumtances, use of Arava has some pre-reqisities. In these cases the doctor and patient should be very caferul while using Arava. If you have turberculosis illness or another lung disease, use of Arava should be reconsidered. 


If the patient is willing to gave a baby in near future, Arava can pave the way for birth defects in the baby can. Men, who want to have baby, should ask their doctor for stopping to use Arava and the period for driving Arava out of body. You should wait at least 3 months for driving it out of body. Then, the patient should have a blood test.


Arava sometimes pave the way for blood, liver and lung problems. It also may contribute to the serious allergic reactions or increase the risk of infection. The blood pressure, blood cells and liver should be checked with a blood test before starting to use Arava. 


What are the Warnings and Precautions for Arava?


- Children and young people, who are under 18 years old, should not use Arava.

- Arava can be used before or after meals.

- You should not use alcohol during Arava treatment

- Do not use Arava if you are pregnant or you feel you are pregnant

- Do not use Arava if you do breastfeeding. 

- ARAVA can reduce your concentration and mobility. Therefore, do not use any vehicle or machine and car.


ARAVA consists of lactose. If you have in tolerance to some sugars, ask and inform your doctor in case of use of Avara. If you are not overly sensitive to other ancillary substances in the content of the ARAVA, adverse effects are not expevted.


Can Avara be used with other Medicines? What are the interactions of Avara with other medicines?


Below drus are not recommended to use with Arava:


- Malaria medicines used in the treatment of rheumatoid arthritis (eg, chloroquine and hydroxychloroquine), D-penicillamine, azathioprine and immunity, drugs that suppress the system (eg methotrexate). 

- Cholestyramine (used to lower high cholesterol) or activated charcoal. 

- Phenitone (used in the treatment of epilepsy), warfarin or fenprocumone (blood used to prevent clotting), tolbutamide (referred to as type 2 diabetes, insulin used in the treatment of non-dependent diabetes) and similar drugs and / or cortisone medications, ARAVA You can continue to use these medicines once you start treatment.


As your doctor, If you have to be vaccinated. If you use Arava, some vaccinations should not be made for a certain period of time. If you are currently using any medicine with or without a prescription, or if you have been using it recently please inform your doctor or pharmacist about these issues.


How is Arava used?


It is recommended to use Arava as your doctor advised. Ask your doctor or pharmacist if you have suspects.


In the starting period, Arava should be taken 100 mg per day. The starting period is 3 days. After the starting period 10 mg to 20 mg per day for rheumatoid arthritis is fine according to the level of the disease. For psoriatic arthritis, it should be taken 20 mg per day. It can take up to at least 4 weeks or more to feel an improvement in your condition. Some patients await up to 4-6 months for the improvement. The treatment shoul not be interrupted before the period foressen. If you interrupt the treatment, you can feel the same symptoms again. 


Arava is taken by mouth. Tablets should be swallowed with enough liquid and as a whole.

How is the specific use of Arava in cases like Kidney failure and Liver failure?

You should not use Arava if you have liver dysfunction and/or moderate or severe kidney problems.


If you forget to get the dose and the time of other dose has not arrived yet, take the normal dose. Do not double the dose if you forget to get. 


What are the Side/Adverse Effects of Arava?


If the person is sensitive to the substances contained in the tablet, there may be side effects in people. If any of the following occurs, stop using Arava and consult your doctor or contact the emergency department of your nearest hospital


- Severe symptoms such as weakness, dizziness, or difficulty in breathing and several allergic reactions 

- Severe and sometimes life-threatening symptoms, such as redness on the skin or ulcers in the mouth 

- Pale skin, tiredness, skin bruises, imbalance in your blood-forming blood cells 

- Fatigue, abdominal pain or jaundice (

- Infection statements such as fever, sore throat or cough 

- Cough or breathing, which can be a sign of inflammation in the lung 


Consult your doctor if you see below effects:


- Significant reduction in white blood cells (agranulocytosis) 

- inflammation of small vessels (including vasculitis, cutaneous necrotizing vasculitis)

- Disturbances in limbs (peripheral neuropathy) 

- Pancreatitis (pancreatitis) 

- Renal insufficiency These are serious side effects and are very rare.


These are serious side effects and observed very rarely. 


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